ASX News

First Patients Dosed in Clinical Trial of Novel Lung and Ovarian Cancer Theranostic

Melbourne and Adelaide (Australia) – 21st September 2020. Telix announces first two patients dosed in phase I trial of lung & ovarian cancer theranostic

Telix Pharmaceuticals Limited is pleased to announce that the first two patients have been dosed in a phase I study of the novel lung and ovarian cancer theranostic APOMAB™, at the Royal Adelaide Hospital (‘RAH’). The clinical study which is being conducted by the Central Adelaide Local Health Network (‘CALHN’) is co-funded by Telix and strategic partner, AusHealth®.

The study, which is being led by RAH Cancer Clinical Trials Unit Head Professor Michael Brown is a two-arm trial of an antibody that targets the La/SSB protein (APOMAB™), initially labelled with Zirconium-89 (89Zr-APOMAB) to enable the biological and targeting properties of the agent to be evaluated using positron emission tomography (PET).

The target of APOMAB, the La/SSB protein, is specifically expressed by cancer cells that have been treated with chemotherapy and/or radiation, and the research objective of the study is to evaluate how well APOMAB is able to potentially deliver diagnostic and therapeutic targeted radiation to advanced lung or ovarian cancers.

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